HYPERTHYROIDISM AND IODIDES

Palladium-catalyzed difluoromethylthiolation of heteroaryl bromides, iodides, triflates and aryl iodides

A palladium-catalyzed difluoromethylthiolation of heteroaryl halides and triflates under mild conditions was described. A vast range of heteroaryl halides such as pyridyl, quinolinyl, benzothiazolyl, thiophenyl, carbazolyl and pyazolyl halides could be difluoromethylthiolated efficiently, thus providing medicinal chemists with new tools for their search of new lead compounds for drug discovery....

Hyperthyroidism.

The thyroid gland is located at the base of the neck, in front of the trachea (windpipe) and esophagus (tube that connects the mouth with the stomach). The thyroid produces thyroid hormone, which helps to regulate many body functions. In hyperthyroidism, the thyroid is overactive and produces more thyroid hormone than the body needs. Women are more likely than men to have hyperthyroidism, and i...

Hyperthyroidism

Hyperthyroidism is a pathological syndrome in which tissue is exposed to excessive amounts of circulating thyroid hormone. The most common cause of this syndrome is Graves' disease, followed by toxic multinodular goitre, and solitary hyperfunctioning nodules. Autoimmune postpartum and subacute thyroiditis, tumors that secrete thyrotropin, and drug-induced thyroid dysfunction, are also important...

Hyperthyroidism.

1. What are the signs and symptoms of hyperthyroidism? General: Heat intolerance, perspiration, flushing, tremor, sleep disturbance, or hair loss. Psychological: Nervousness, emotional lability, anxiety, aggressiveness, or delusions. Cardiovascular: Palpitations, tachycardia, or supraventricular dysrhythmias. Respiratory: Breathlessness or hoarseness. Gastrointestinal: Increased appetite, weigh...

Hyperthyroidism.